The crystals that wiped out an HIV medication, almost overnight. Thanks to SoFi for sponsoring the video! Click here to sign-up for SoFi Checking and Savings: https://sofi.com/ve

If you’re looking for a molecular modelling kit, try Snatoms, a kit I invented where the atoms snap together magnetically - https://ve42.co/SnatomsV

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Check out the excellent video by Reactions here: https://youtu.be/PccOwGEbtQU?si=NOpmaulDcoq6Kif-

This video was a huge collaborative effort!

Special thanks to…

Dr Andreas Kafizas for all his help with the Silver and Tin demonstrations, and staying up for those 14 hours with us monitoring the timelapse! As well as Conrad Duncan and the team at Imperial College London.

@ChrisYoungCooks for teaching Casper how to temper chocolate and @jameshoffmann and the team for letting us take over their studio; we had a great day!

Many thanks to Professor Adam Matzger, Professor Katharina Fromm and Professor Mike Zaworotko for taking the time to talk to us.

Also thank you to Dr. William McVicker and the British Institute of Organ Studies and Chris at Luciteria Science for helping us source our grey and white tin samples.

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0:00 The Disease Infecting Miracle Medicine

4:20 An Explosive Feud

10:05 How The Same Compound Can Behave Two Different Ways

13:18 Polymorphs Of Chocolate

19:51 Why Ritonavir Stopped Working

22:57 The Tin Pest

27:28 Disappearing Polymorphs

30:20 Is Everything Polymorphic?

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References can be found here - https://ve42.co/PolymorphRefs

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Special thanks to our Patreon supporters: Adam Foreman, Albert Wenger, Alex Porter, Alexander Tamas, André Powell, Anton Ragin, Balkrishna Heroor, Bertrand Serlet, Blake Byers, Bruce, Bryan Ackermann, Cartier, Chris Brewer, Daniel Martins, Data Don, Dave Kircher, David Johnston, David Tseng, EJ Alexandra, Evgeny Skvortsov, Garrett Mueller, Gnare, gpoly, Hayden Christensen, Hong Thai Le, Ibby Hadeed, Jeromy Johnson, Jesse Brandsoy, Juan Benet, Kelcey Steele, KeyWestr, Kyi, Lee Redden, Marinus Kuivenhoven, Mark Heising, Martin Paull, Meekay, meg noah, Michael Krugman, Orlando Bassotto, Parsee Health, Paul Peijzel, Richard Sundvall, Robson, Sam Lutfi, Shalva Bukia, Sinan Taifour, Tj Steyn, Ubiquity Ventures, Vahe Andonians, William Yoon, wolfee

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Writers: Gabe Strong & Casper Mebius

Producer and Director: Gabe Strong

Presenters: Derek Muller & Casper Mebius

Editor: Trenton Oliver

Assistant Editor: James Stuart

Illustrators: Jakub Misiek, Emma Wright & Maria Gusakovich

Animators: Fabio Albertelli, Andrew Neet, Emma Wright & Alex Drakoulis

Researcher: Sophia Rose

Additional Research: Callum Cuttle

Camera Operators: Rob Newman, Casper Mebius, Gabe Strong, Callum Cuttle & Derek Muller

Voice-over Artist: Gregor Čavlović

Thumbnail Designers: Abdallah Rabah, Ren Hurley & Ben Powell

Production Team: Jess Bishop-Laggett, Glen Griffiths, Mathew Cavanagh & Anna Milkovic

Executive Producers: Derek Muller, Casper Mebius & Gregor Čavlović

Additional video/photos supplied by Getty Images & Storyblocks

Music from Epidemic Sound